Sanctuary follows the adventures of the enigmatic Dr. Helen Magnus (Amanda Tapping), forensic psychiatrist Dr. Will Zimmerman (Robin Dunne) and her fearless daughter Ashley (Emilie Ullerup). Together they track down, study and protect the strange and often terrifying creatures that secretly populate our world. Rather than dismiss the creatures as monstrous figments of our imaginations, Dr. Magnus recognizes that the world is full of nature's mistakes and triumphs and has the spectacular proof that they are indeed real. Dr. Zimmerman, an insightful psychiatric profiler with a knack for finding the strange and curious, reluctantly joins the team to aid in the study of beings he can hardly believe himself. Together with Ashley and quirky tech-whiz Henry, they use instinct, medicine, and cutting-edge technology to find the creatures that lurk in the corners of our civilization and protect us from those too dangerous to be roaming free.